CDKN2A and lung carcinoma: In addition to the selected DMR combinations that showed the highest diagnostic performance, individual DMRs located in other genes crucial for cell cycle regulation, DNA repair, and cellular functions such as CDKN2A, DAPK, MLH1, and Septin9, which were previously reported as hypermethylated in lung cancer samples [50,51,52], showed high efficacy in distinguishing lung cancer from benign conditions during the marker screening study.