LATS1 and renal cell carcinoma: Inducible genetic ablation of Lats 1/2 in the proximal renal tubules in adult mice (generated by a crossing of tamoxifen-inducible proximal tubule-specific Cre line -Slc34a1CreERT2 with Lats1/2 floxed mice) resulted in the formation of a high-grade sarcomatoid RCC phenotype within 4 months with metastasis to the lung [28].