TNK2 and neoplasm: For example, the phosphorylation of Wiskott–Aldrich syndrome protein (WASP) by Ack1 has been reported to promote its actin remodeling activity [28], while the phosphorylation of p130Cas, a component of focal adhesion and a member of the Cas (Crk-associated substrate) family, by Ack1 is associated with tumor invasion, promoting cell spreading [43] and cell migration [44].