PVT1 and cancer: Inhibition of PVT1 transcription was associated with a 40% increase in the proliferation rate of breast cancer xenografts, with MYC being responsible for accelerating cancer cell growth, as confirmed through ASO (antisense oligonucleotides [59]) and shRNAs (short hairpin RNAs [60]) knock-down (KD) strategies coupled with transcriptome analysis.