Despite the above limitations, the potential biomarkers presented in the current study, the differentially expressed proteins CD166 and S100A13, as well as the miRNA miRNA-1285-3p and their target proteins TGM2 and CDH-1, represent a potential major advance in the search for biomarkers for the diagnosis of PDAC enabling early detection of PDAC in DM patients in the future. The gene discussed is CDH1; the disease is diabetes mellitus.