CCND1 and melanoma: However, some reports suggest that the expression of cyclin D1 is upregulated upon treatment with HDACi like valproic acid in human melanoma cells [56], butyrate in vascular smooth muscle cells [51,57,58], MHY219 in prostate cancer cells [59], SAHA in rhabdoid tumors [60], and valproic acid in renal cell carcinoma [61] and lung cancer cells [62].