ADA2 and familial pancreatic carcinoma: Our study shows, for the first time, that the pharmacologically targeted combination of Abe and Pan is synergistic and effective in killing pancreatic cancer cells, as depicted by the clonogenic potential (Figure 4), combination synergy studies (Figure 3 and Figure S2), and the live-dead assay of 3D spheroids and spheroid growth studies (Figure 8).