P2RX7 and primary cutaneous T-cell non-Hodgkin lymphoma: Indeed, P2X7 or calcineurin (NFAT) inhibition reduced the viability of CTCL cultures, as already demonstrated for B-cell leukemia cells [38], and negatively interfered with H-1PV-induced cytotoxicity (A.A., unpublished observations), suggesting that P2X7-mediated signaling may favorably contribute to the efficiency of H-1PV-induced oncolysis in CTCL cells.