The most significant tumor-associated metabolites included 2-hydroxyglutarate (FC = 20.5×; p = 6.8 × 10−6), a well-characterized oncometabolite of IDH-mutant tumors [11,15], N,N,N-trimethyl-5-aminovalerate (FC = 2.9×; p = 6.8 × 10−6) and asparagine (FC = 2.6×; p = 6.8 × 10−6) (Figure 2C). This evidence concerns the gene IDH1 and neoplasm.