WNT5A and neoplasm: With regard to calcium signaling, Wnt5a exhibits tumor suppressor function in several tissue and tumor types, such as neuroblastoma [142,143], esophageal squamous cell carcinoma [144], acute myeloid lymphoma [145,146,147], breast cancer [148,149,150], thyroid carcinoma [151], and colon carcinoma [152,153].