While upregulation of Wnt/PCP components enhances cell migration, invasion, and metastasis in various tumor types, including breast cancer [125,128,129], prostate cancer [130], gastric cancer [131,132], colorectal cancer [133,134], and glioblastoma [127], depletion of PRICKLE1 and MINK1 has been linked with reduced cell motility in breast cancer [141]. The gene discussed is PRICKLE1; the disease is breast cancer.