Together, the roles of Tip60 in chromatin remodeling and transcription support the need to use precise and tunable Tip60 inhibitors to better understand the epigenetic roles of Tip60 in each tissue type (without the confounding effects of apoptosis induction due to the genetic/transcript loss of Tip60) and as potential epigenetic therapeutics for the treatment of cancer and other diseases, including neurological and immune disorders. This evidence concerns the gene KAT5 and immune system disorder.