The Tip60–Foxp3 interaction enhances both the stability and transcriptional activity of Foxp3, where Tip60 acetylates Foxp3, preventing its polyubiquitination and degradation, ensuring increased protein levels [47], which promotes the suppressive Foxp3 Treg functions, helping drive tumor immunity [46,48,49,50,51]. This evidence concerns the gene KAT5 and neoplasm.