IDH2 and Huntington disease: To investigate the direct effects of recurring AML IDH1/2 mutations, hCD34+ cells from HD were transduced by a lentiviral expression vector, containing either IDH1 wild-type or IDH1-R132H, along with a ZsGreen1 reporter gene (n = 7 donors), or containing either IDH2 wild-type or IDH2-R140Q, also with a ZsGreen1 reporter gene (n = 6 donors) (Supplementary Table S1), and sorted as described in the Materials and Methods section.