CD274 and neoplasm: In ovarian cancer, IFNγ induces the expression of the cancer antigen CA-125 (MUC-16) [45], human leukocyte antigen-E (HLA-E) [46], the immune checkpoint ligand PD-L1 [36,38,47,48,49], the proto-oncogene Bcl3 [47,50], and the pro-angiogenic and pro-inflammatory chemokine IL-8 [50,51], resulting in increased proliferation and migration of OC cells, immune escape, and tumor growth (Table 1).