In this review, we summarize the current knowledge on the mechanisms by which IFNγ induces the expression of Bcl3, PD-L1 and IL-8/CXCL8 in cancer cells, with a special focus on ovarian cancer, and highlight the importance of a better understanding of these mechanisms to optimize the development of combinatorial approaches in cancer immunotherapies. This evidence concerns the gene CXCL8 and cancer.