Interleukin-8 (IL-8, CXCL8), which was originally discovered as a neutrophil chemoattractant and inducer of leukocyte-mediated inflammation, plays a crucial role in cancer progression through its induction of tumor cell proliferation, migration, invasion, angiogenesis and metastasis [142,143,144,145]. This evidence concerns the gene CXCL8 and neoplasm.