We found a near total loss of PD-L1 in the tumor-bearing animals that received 3′UTRMYC1-18 (Figure 4A) and mild levels of PD-L1 in the 3′UTRMYC2-3- and 1-14-treated tumors (Figure 4A), whereas the untreated controls had very high levels of PD-L1 (Figure 4A). Here, CD274 is linked to neoplasm.