We found that the destabilized c-MYC constructs degraded c-MYC mRNA expression (Figure 2H) as well as c-MYC interacting partners with a known high MYC binding site, MAX, MGA, SAT1, NPM1, LYAR, STAT5A/B, NOTCH2, NOTCH3, EP300, GSK3B, SKP2, MXD1, AURKA, CD274, POLII, WNT11, ASCL1, JUNB, NAT16, VEGFA, TLL1, TAL2, JUN, PDGFB, and EGR1, in the cancer cells carrying the destabilized 3′UTRMYC1-18. This evidence concerns the gene EP300 and cancer.