Moreover, a model combining CYFRA 21-1, CEA, ProGRP, and NSE was shown to perform better (AUC = 0.86) and with a higher sensitivity when compared to CYFRA 21-1 alone for NSCLC diagnosis, and a panel of CA125, CA15.3, CYFRA 21-1, NSE, ProGRP, and DNA was superior to individual TMs when diagnosing SCLC. Here, ENO2 is linked to small cell lung carcinoma.