The CEA level (AUC: 0.812; 63.9% sensitive) was the highest related to ADC; CYFRA 21 (AUC: 0.847; 84.6% sensitive) and CEA (AUC: 0.804; sensitivity: 70.0%) were the best suited for SCC and NSE (AUC: 0.819; 69.0% sensitive), and CEA (AUC: 0.808; 60.7% sensitive) was the highest in regard to SCLC. The gene discussed is ENO2; the disease is small cell lung carcinoma.