Regardless of the underlying mechanism, the presence of squamous components may contribute to both the more aggressive behavior of these tumors and to certain paraneoplastic syndromes, such as parathyroid hormone-related protein (PTHrP)-mediated hypercalcemia that has been reported with some cases of colonic ASC [17,18,19]. Here, PTHLH is linked to Tako-tsubo cardiomyopathy.