There were no significant differences in p-DFS and p-EFS between patients re-exposed (ASP+) and not re-exposed to asparaginase (ASP−) after the first episode of AP (0.78 vs. 0.86, log-rank p = 0.27 and 0.63 vs. 0.79, log-rank p = 0.09, respectively). This evidence concerns the gene ASPG and alkaline phosphatase measurement.