For this study, we isolated exosomes from three melanoma cell lines: Malme-3M, SK-MEL-28, and SK-MEL30, each treated with the following conditions: either hGH or doxorubicin alone, hGH and doxorubicin, or a combination of hGH, doxorubicin, and pegvisomant (a GHR antagonist) [53,54,55]. This evidence concerns the gene GH1 and melanoma.