Changes in DNA methylation are a hallmark of cancer [114] and were found in HSCs harboring CH mutations, including mouse models of Dnmt3a−/− [107], Dnmt3aR878H/+ [115], Tet2−/− [116], Tet2+/− [117], and Asxl1 [118]. This evidence concerns the gene ASXL1 and cyclic hematopoiesis.