TNF and cyclic hematopoiesis: While these findings suggest that mutant macrophages might be commonly deregulated in CH, evidence for increased inflammatory cytokine production was also found in asxl1- [71], Tet2- [72], and Runx1-mutant neutrophils [73], and Dnmt3a-deficient mast cells [74], which produce more IL-6, TNF-α, and IL-13 [74].