Possible mechanisms speculated for the development of hypertension in insulin‐resistant individuals are via (a) endothelial dysfunction resulting from pathway‐specific impairment in PI3K‐dependent signaling28 and/or, (b) activation of the renin‐angiotensin‐aldosterone system with compensatory hyperinsulinemia in insulin‐resistant conditions.38 This evidence concerns the gene REN and hypertensive disorder.