DYSF and neuromuscular disease caused by qualitative or quantitative defects of dysferlin: These histopathological observations accord with proteomic analyses identifying alterations in muscle damage, repair, and remodelling pathways and infiltration of inflammatory/immune cells in quadriceps from human dysferlinopathy patients [21] and dysferlin-deficient BLA/J mice [22], and also gene expression analyses of human dysferlinopathy patients [23].