Further expanded the normal sample size (TCGA + GTEx) (Fig. 1C), we found that DCHS1 was highly expressed in GBM, Glioma (GBMLGG), Brain Lower Grade Glioma (LGG), HNSC, KIRC, WT, PAAD, TGCT, ALL, LAML, PCPG and CHOL, while underexpressed in UCEC, BRCA, CESC, LUAD, ESCA, STES, KIRP, COAD, Colon adenocarcinoma/Rectum adenocarcinoma Esophageal carcinoma (COADREAD), PRAD, LUSC, SKCM, BLCA, THCA, OV, UCS, ACC and KICH. This evidence concerns the gene DCHS1 and central nervous system cancer.