SENP3 and esophageal squamous cell carcinoma: Univariate regression analysis revealed that lymphovascular invasion (p < 0.001), primary lesion SUVmax ≥ 8 (p = 0.003), and relatively low expression of SENP3 in CD206-positive cells (p = 0.011) were significantly associated with lymph node metastasis in ESCC patients (Fig. 6A).