VEGFA and endothelial dysfunction: The most prominent feature of this disease is endothelial dysfunction, which is caused by the release of soluble Fms-like tyrosine kinase 1(sFlt1), soluble endoglin and low levels of proangiogenic factors like placental growth factor (PlGF), vascular endothelial growth factor (VEGF) from the ischemic placenta into maternal plasma [7].