RUNX2 and cleidocranial dysplasia 1: However, there is some evidence that Wingless-related integration site (Wnt) signalling activity is required in odontogenic mesenchyme for the suppression of successional tooth formation and Runx2 may be involved in suppressing the activity of Wnt inhibitors in these regions as part of this process.36 This suggests that, in human tooth development, elevated Wnt signal levels in the mesenchymal component of the developing dentition might be the basis of continued successional tooth formation taking place in CCD subjects.