VCP and frontotemporal dementia: Dominantly inherited missense mutations in p97 are associated with a rare multisystem degenerative disorder known as inclusion body myopathy with early-onset Paget disease and frontotemporal dementia (IBMPFD) which is characterized by four main phenotypes: inclusion body myopathy (muscle), Paget’s disease of bone (bone), frontotemporal dementia (brain), and familial amyotrophic lateral sclerosis (fALS)15,16.