ACTA1 and Hepatic fibrosis: In contrast to Foxo1M-KO, Foxo1/Notch1M-DKO augmented liver fibrosis (Fig. 6i), with concomitant increases in the mRNA expression of profibrotic genes, including αSMA, Col1α1, TGF-β1, CCL2, and TIMP1, in the liver after HFD feeding (Fig. 6j).