Compared with the WT mice, the Foxo1/YAPM-DKO mice exhibited significantly increased serum ALT levels (Fig. 8e), liver fibrosis (Fig. 8f), and mRNA levels of αSMA, Col1α1, TGF-β1, CCL2, and TIMP1 in the HFD-challenged livers (Fig. 8g). This evidence concerns the gene FOXO1 and Hepatic fibrosis.