In HCC cell lines, DDX5 interacts with the epigenetic silencing PRC2 complex [9], controls STAT1 translation by resolving a G-quadruplex located at the 5’UTR of the STAT1 mRNA [10], and its knockdown (DDX5KD) leads to hepatosphere formation [11]. The gene discussed is DDX5; the disease is hepatocellular carcinoma.