SPP1 and metabolic dysfunction-associated steatohepatitis: Importantly, our analyses of the transcriptomic data from the NASH to HCC STAM model [28, 29], identified increased expression of the DDX5-dependent and interlinked genes and pathways, including Dvl1, 2, 3 (associated with Wnt/β-catenin activation), Map3k14, Nfkb2, Relb (related to non-canonical NF-κB), and Nrf2 along with NRF2-induced genes Nqo1, p62/Sqstm1 and Spp1 (Fig. 8A).