Interestingly, several studies corroborate the context-specific effects of complete Cyld protein deficiency in different cell types, such as gingival fibroblasts in periodontal diseases, where TNF and LPS exerted differential NF-κB outcomes [42] or in Cyld-deficient macrophages and T-cells which differentially respond to innate (TNF, LPS) or adaptive (anti-CD3) stimuli respectively [43, 44]. Here, NFKB1 is linked to periodontal disorder.