In addition, screening of exome data from three independent cohorts of infertile men identified eight additional patients with homozygous high-impact variants (two LoF and six missense) in GPAT2, PIWIL2, MOV10L1, and TDRD12 (Table 1, Supplementary Data 1), bringing the total number of variant carriers to 39. The gene discussed is PIWIL2; the disease is Infertility.