Over the years, multiple hypotheses have been proposed to explain the pathogenesis of AD, including the amyloid cascade hypothesis [57], the Tau propagation hypothesis [58], the cholinergic hypothesis [59], the calcium homeostasis hypothesis [60], the neuroinflammation hypothesis [61], the mitochondrial cascade hypothesis [62], and the metal ion hypothesis [63], to name a few. Here, MAPT is linked to Alzheimer disease.