A shift to sympathetic predominance has been previously linked to proinflammatory cytokine production, hyperglycemia, and increased blood-brain barrier permeability.[43,44] Herein, the conditions of patients were relatively mild, and the ultra-early stress reaction may not have been severe following the NIHSS scores at admission and C-reactive protein levels, thereby minimally affecting BPV. The gene discussed is CRP; the disease is Hyperglycemia.