AKT1 and lung adenocarcinoma: Notably, HOTTIP overexpression also negatively regulates HOXA13.[54] Furthermore, the overexpression of HOTTIP contributes to drug resistance in lung adenocarcinoma through the modulation of AKT signaling pathways.[55] Collectively, these findings suggest that HOTTIP, as a lncRNA, serves as a crucial marker in the development of pulmonary carcinoma.