LDLR and familial hypercholesterolemia: Patients with hypothyroidism often showed abnormal lipid profile such as hypercholesterolemia and hypertriglyceridemia, which was caused by decrease in the number and activity of LDL receptors and lipoprotein lipase activity on the surface of cells.[5,6] Kotwal et al[7] found that hypothyroidism patients with L-T4 therapy exhibited a significant decrease in the serum level of TC, TG, LDL-c, and HDL.