Although the study could not find a statistical difference in serum IgE levels and peripheral eosinophil count, clinical efficacy could be demonstrated.[16] In another study, treatment with NSO (40–80 mg/kg/day for 8 weeks), resulted in a reduction of eosinophil count, IgE, in patients with allergic disorders including rhinitis, atopic eczema, and bronchial asthma.[25]. This evidence concerns the gene IGHE and rhinitis.