Moreover, anxiety itself serves as a risk factor for GDM because it stimulates the sympathetic adrenal medullary system; promotes ACTH secretion; increases levels of glucocorticoids, insulin, and catecholamines; and ultimately accelerates gluconeogenesis and glycogenolysis, further increasing blood glucose levels.[29] This indicates an interaction between changes in blood glucose levels and anxiety. Here, POMC is linked to Anxiety.