MMP2 and nasopharyngeal carcinoma: Then, the expression of MMP‐2 in NPC cells was determined by western blotting, and the results revealed that ISL significantly downregulated the MMP‐2 expression in both NPC‐39 and NPC‐BM cells to 45.4% and 30.4% in a dose‐dependent fashion, respectively (p < 0.05 compared with control).