Higher baseline levels of most proteins (SNAP-25, NfL, Ng, β-syn, γ-syn, AP2-complex subunit β [AP2], GDI-1, PEBP-1, all 14-3-3 proteins and CPLX2) were also associated with faster cognitive decline (interaction protein*time p < 0.05). The gene discussed is PEBP1; the disease is Mental deterioration.