In previous studies levels of neuronal pentraxins (NPTX) were decreased, while synaptotagmin-1 (SYT1) levels were increased in AD compared to controls.13,16,18 - 20 Previously, we found that CSF levels of proteins involved in synapse function were specifically elevated in mild cognitive impairment (MCI)-AD patients, while levels in controls and AD dementia patients were similar to each other.21 Here, SYT1 is linked to Cognitive impairment.