There was a significant interaction with group for SYT1, NPTX1, NPTX2, and NPTX-R; slopes of AD dementia patients (st.B[SE] –0.15[0.05], –0.11[0.04], –0.13 [0.04], and –0.10[0.04] respectively) differed from those of SCD/MCI-A– subjects. The gene discussed is SYT1; the disease is Schnyder corneal dystrophy.