CD40LG and diabetes mellitus: The reason for comparable opsonic titers between obese diabetes and obese non-diabetes individuals could be the comparable production of anti-capsular antibodies between obese diabetes and obese non-diabetes individuals and the role of additional influencing factors like anti-capsular IgM in the determination of opsonic titers [98–100], also suggesting that once antibodies are produced they may be equally functional in both obese and non-obese further confirming the fact that problem arises at the level of antibody production which may be the result of poor glycemic control.