In addition, doxorubicin treatment significantly upregulated the expression of NLRP3, ASC, N-GSDMD, IL-18, and IL-1β and inhibited the YAP/TEAD pathway in the myocardial tissues of the HF rats; however, these changes were reversed by TAOK1 overexpression (Fig 7C–7E). This evidence concerns the gene IL18 and hydrops fetalis.