Intriguingly, in EM lesions from CNR1 k/o and CNR2 k/o, we saw significantly elevated expression of monocytes/macrophages (Figure 7D), stromal cells (Figure 7E), and hallmarks of EM such as proliferation and vascularization (Figure 7F) demonstrating an altered microenvironment in the absence of these receptors. Here, CNR1 is linked to erythema multiforme.