LNP delivery strategy is a revolutionary therapeutic development, enabling the delivery of siRNA, mRNA, DNA, and small molecular drugs.[15] The folate receptor (FR) is upregulated in many human tumors and recently a study using a folate‐labeled LNP delivery system targeting ICC showed superior anti‐tumor effects.[34, 35] The result of qRT–PCR verified that FR alpha (FOLR1) was overexpressed in RBE cells in comparison to HiBEC cells (Figure S6A, Supporting Information). Here, FOLR1 is linked to intrahepatic cholangiocarcinoma.