In summary, the present study identified circUGP2 as a tumor suppressor in ICC by interacting with PURB to co‐activate ADGRB1 transcription, as well as sponging miR‐3191‐5p to upregulate ADGRB1 expression, leading to the activation of p53 signaling pathway. Here, TP53 is linked to intrahepatic cholangiocarcinoma.