IL6 and intrahepatic cholangiocarcinoma: constructed LNPs encapsulating plasmids loading human CAR gene and IL‐6 shRNA, which successfully established CAR‐T cells with IL‐6 knockdown in mice.[47] Recently, a circRNA study utilized a folate‐labeled LNP system co‐loaded with siRNA and paclitaxel to target ICC, showing superior anti‐tumor effects.[35] Based on these studies, we established an LNP system to encapsulate circUGP2 plasmid using folate‐conjugated DSPE‐PEG2000, which successfully targeted the tumor site.