RFNG and colorectal carcinoma: To explore whether RFNG metabolic activity is essential for its function in CRC chemoresistance, we restored RFNG expression using a synonymously mutated shRNA‐resistant RFNG wild‐type (rRFNG WT) and an enzymatically dead (ED) rRFNG variant in RFNG‐depleted HCT116 and LS174T cells (Figure S1N, Supporting Information).