RFNG and neoplasm: Accumulating evidence has indicated that p53 plays a role in regulating ferroptosis, which contributes to tumor suppression.[19] RNA‐seq analysis revealed that the expression of the ferroptosis‐negative regulatory gene SLC7A11, which is known to be transcriptionally inhibited by p53,[8] was reduced in RFNG‐depleted cells, while the impact on other p53‐regulated genes[20] involved in ferroptosis was relatively minor (Figure 2E).