There are three main iron‐induced death defense systems: the SLC7A11‐GSH‐GPX4, NAD(P)H‐FSP1‐CoQ10, and GCH1‐BH4/BH2 system.[35] The cystine/glutamate antiporter SLC7A11 (also known as xCT) is often overexpressed in various human cancers, and studies have shown that its overexpression promotes tumor growth by suppressing ferroptosis.[36, 37] In our study, we discovered that high‐level phosphorylation of RFNG in cells leads to its nuclear localization, where it inhibits p53 and promotes the expression of SLC7A11 during oxaliplatin chemotherapy. Here, GCH1 is linked to neoplasm.