RFNG and colorectal carcinoma: The results showed that both rRFNG WT and ED fully restored the RFNG depletion‐enhanced sensitivity of CRC cells to oxaliplatin, excluding the possibility of off‐target effects of RFNG shRNAs, which indicated that RFNG metabolic activity is not essential for its function in CRC chemoresistance (Figure 1I; Figure S1O, Supporting Information).