Notably, two well‐established genes in the p53 pathway, CDKN1A and SERPINB5, which are known to promote tumor cell apoptosis,[17, 18] exhibited increased expression upon RFNG knockdown, which was rescued by restoration of rRFNG WT or ED expression in RFNG‐depleted cells after oxaliplatin treatment (Figure 2D; Figure S2C, Supporting Information). This evidence concerns the gene CDKN1A and neoplasm.