MFNG and colorectal carcinoma: For example, LFNG has been found to function as a tumor suppressor,[11] while MFNG acts as an oncogene in breast cancer.[12] In addition, LFNG has been implicated in promoting CRC progression through its involvement in the activation of Notch signaling.[13] However, most studies have focused on the enzymatic activity of fringe members in modifying Notch proteins, and it remains unclear whether fringe members play a role in CRC chemoresistance through non‐enzymatic mechanisms.