TP53 and neoplasm: There are three main iron‐induced death defense systems: the SLC7A11‐GSH‐GPX4, NAD(P)H‐FSP1‐CoQ10, and GCH1‐BH4/BH2 system.[35] The cystine/glutamate antiporter SLC7A11 (also known as xCT) is often overexpressed in various human cancers, and studies have shown that its overexpression promotes tumor growth by suppressing ferroptosis.[36, 37] In our study, we discovered that high‐level phosphorylation of RFNG in cells leads to its nuclear localization, where it inhibits p53 and promotes the expression of SLC7A11 during oxaliplatin chemotherapy.