SLC12A3 and Hypertension: A genome-wide association study revealed that common variants in the UMOD promoter associated with lower UMOD expression are also associated with a reduced risk of arterial hypertension and cardiovascular events.77 Individuals with UMOD promoter variants associated with higher expression of UMOD displayed an enhanced response to furosemide with respect to BP reduction.78 Whether higher NCC activity contributes to the hypertensive effects of UMOD promoter variants that raise BP has not been determined.