Dsg1 loss in keratinocytes has also been shown to regulate proliferation of adjacent melanocytes in melanomas, which can further repress keratinocyte Dsg1 through paracrine signaling, promoting a feed-forward cycle (Baron et al., 2023, Preprint; Burks et al., 2023; Arnette et al., 2020). The gene discussed is DSG1; the disease is melanoma.