Direct injection of osteocalcin into the right striatum of PD rats improves motor dysfunction induced by 6‐hydroxydopamine and reduces the depletion of dopamine neurons through the AKT/gsk3β signaling pathway.[293] Additionally, osteocalcin can improve PD symptoms by reducing the expression of inflammatory factors and inhibiting the proliferation of astrocytes and microglia.[294]. This evidence concerns the gene AKT1 and Parkinson disease.