SOD1 and amyotrophic lateral sclerosis: An imbalance in the composition of intestinal microbiota may be an environmental factors contributing to the development of ALS.[187] Research has demonstrated that the levels of several butyricogenic bacteria that are important for intestinal completion and inflammation regulation are lower in patients with ALS.[188] Experimental evidence using ALS‐susceptible Sod1 transgenic mice has demonstrated that Akkermansia muciniphila can improve the symptoms of ALS, whereas Ruminococcus and Desulfovibrio exacerbate the disease.[189]