Specifically, CTSC is a lysosomal cysteine protease, and its knockdown inhibits cell proliferation and enhances senescence in tumor cells.30 Endogenous level of SORBS2 increase with keratinocyte senescence,31 and E2F7 accelerates oncogene-induced senescence.32 Our results showed that the expression of these genes was dependent on the replicative senescence of WJ-MSCs and GLS1 inhibition. Here, CTSC is linked to neoplasm.