A majority of these canonical pathways were associated with the immune response, i.e., cytokine signaling (interferon signaling, ISG15 antiviral mechanism interleukin-1 family signaling), cellular immune system (Systemic Lupus Erythematosus in B Cell Signaling Pathway, role of PKR in interferon induction and antiviral response and T cell receptor signaling), adaptive immune system (Class I MHC-mediated antigen processing and presentation), and innate immune system (DDX58/IFIH1-mediated induction of interferon-alpha/beta and cytosolic sensors of pathogen-associated DNA) responses (Figure 10B). The gene discussed is ISG15; the disease is systemic lupus erythematosus.