It has been well documented that PPARα activators suppress CYP7A1 gene promoter activity in human hepatoma HepG2 cells [51,52] and that PPARα agonists, e.g., fenofibrate, downregulate cyp7a1 and cyp27a1 expression and reduce their activity in rodents [53]. The gene discussed is CYP7A1; the disease is hepatocellular carcinoma.