ANGPT2 and neoplasm: For now, it is well established that VEGF, FGF-2, and ANG-2 upregulate MT1-MMP, MMP-2, and MMP-9 expression (Table 1; Figure 2): consistently, a positive correlation has been observed between the levels of these angiogenic factors and those of MT1-MMP, MMP-2 or MMP-9 in tumor tissues [120,121,122,123,124,125,126,127,128,129,130,131,132].