Nevertheless, the exposure of pancreas carcinoma cells to VEGF-A is followed by the nuclear translocation of beta-catenin and an increase in SNAI and TWIST expression: this, in turn, causes pancreas carcinoma cells to acquire EMT features such as a reduction in E-cadherin levels and the concomitant induction of N-cadherin and vimentin expression [108] (Table 1). This evidence concerns the gene TWIST1 and familial pancreatic carcinoma.