In agreement with their capability of upregulating HIF-1, both VEGF and FGF-2 increase GLUT-1 expression in endothelial cells [166,167,168] (Table 1; Figure 2): as for FGF-2, it is likely that this can guarantee the optimal use of glucose via the nascent tumor vessels even in conditions of normoxia. Here, VEGFA is linked to neoplasm.