Prompted by this need, here, we have discussed published findings indicating that VEGF, FGF-2, and ANG-2 are upregulated in OPMD and OSCC, where they activate the PI3K/AKT and MAPK/ERK pathways that, in turn, lead to EMT and concomitant vessels generation. Here, AKT1 is linked to oculopharyngeal muscular dystrophy.