PLAU and carcinoma: Thanks to the joint activity of the integrins, the actin/myosin complexes, and the GTPases, carcinoma cells deform their cytoskeleton so to enhance their migratory capabilities as much as possible: then, the single carcinoma cells invade the peritumoral ECM via the proteolytic activity of MMPs and/or uPA [3,10,15,16,173].