Additionally, CTRP13 was shown to preserve endothelial function in diabetic mice by regulating endothelial nitric oxide synthase (eNOS) coupling [16], preventing vascular calcification through destabilization and degradation of the master transcription factor for osteogenesis Runx2 [17], and reducing the incidence and severity of abdominal aortic aneurysm (AAA) through reduced aortic macrophage infiltration [18]. Here, NOS3 is linked to abdominal aortic aneurysm.