The vasoprotective effects of adiponectin involve increased EC proliferation and migration, NO release [30], inhibition of atherogenic factors such ICAM-1 or E-Selectin [3], reduced monocyte adhesion [31], or priming of monocyte differentiation into anti-inflammatory M2 macrophages [32], and thus intervening in early arteriosclerosis events. The gene discussed is ADIPOQ; the disease is arteriosclerosis.